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The following study estimates the cost of burnout on early retirement and reduction in clinical hours of practicing physicians in Canada through data collected from the January 2012 Canadian Medical Association Masterfile and the 2007 National Physician Survey. The cost of burnout associated with early retirement and reduction in clinical hours is substantial and a significant proportion of practicing physicians experience symptoms of burnout. As health systems struggle with human resource shortages and expanding waiting times, this estimate sheds light on the extent to which the burden could be potentially decreased through prevention and promotion activities to address burnout among physicians.